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Item Type:ArticleItem Status:Live ArchiveAbstractLarge artery atherosclerotic stroke (LAS) shows substantial heritability not explained by previous genome wide association studies. Here, we explore the role of coding variation in LAS by analyzing variants on the HumanExome BeadChip in a total of 3,127 cases and 9,778 controls from Europe, Australia, and South Asia. Using quantitative microscale thermophoresis, we show that M1 (A213) exhibits an almost twofold lower dissociation constant with its primary target human neutrophil elastase (NE) in lipoprotein containing plasma, but not in lipid free plasma.
Calgary based Enbridge says the Line 3 project is necessary to ensure the reliable delivery of crude to Midwestern refineries. The company says the existing line, which was built in the 1960s, is subject to corrosion and cracking and can run at only half its original capacity because of its accelerating maintenance needs. The Jobs for Minnesotans coalition of business, labour and community leaders backs the project, saying it will create 8,600 well paying jobs with a total economic impact on the state of $2 billion..
While most competitive marathoners log 100 or 120 miles a week, Clark puts in just 50 to 70 miles, plus one session of weight training. When the temperature gets Arctic and the roads are slick and icy, Clark simply laces up indoors, bounding along to nowhere for about an hour and a half each day on her treadmill. To stave off boredom, she cues up movies in the television and VCR.
All times are ET. Disclaimer. Morningstar: 2018 Morningstar, Inc. Madsen is a three time Paralympian from Nebraska City, Neb. Who has won eight Paralympic medals, including two golds in the 100 and 200 meters at the Sydney games in 2000. Madsen left racing for 13 years, returning to competition for the 2013 world championships in memory of her younger brother, Mario III, and their father, Mario Jr., who were killed in a car train crash in 2007.
St. Johns became part of Portland in 1915 and today perhaps best epitomizes the city’s mix of old and new. Many of the very vintage establishments here might be mistaken for imitation retro outposts in another part of town, but most of them are in fact family owned spots that are actually many decades old..
When, and with what, this trend started is probably indeterminable but the successful launch of an electric shaver for women in the 1940s got the ball rolling. There is neither need nor space for his and her refrigerators.” Evidently, the beer fridge is a foreign concept to him. But his point stands, pink electric shavers for “ladies” only exist because women see some advantage in using them over the standard “male” version..